If the sentence is negative, then for singular nouns we use there isn’t a or there’s nota (there is not a) and there aren’t any (there are not any) for plural.
There isn’t a pharmacy near the hotel.
There aren’t any restaurants near the hotel.
You can also use there is no + uncountable noun and there are no + plural noun.
There’s no water.
There are no people in the crowd.
We can use there is and there are in other tenses.
There was match on TV last night.
There were a lot of people in the mall yesterday.
There will be a lot of traffic tomorrow